Concept, design, implementation & completion
The team at the Institute of Pharmacovigilance Sciences has expertise in the concept, design, implementation, and completion of methodological studies, as well as a broad range of experience in pharmacovigilance and pharmacoepidemiology.
At the DSRU, we are committed to evaluation of current methodologies in pharmacoepidemiology and pharmacovigilance, and consideration of how these can be improved.
All methodological work carried out at the DSRU is communicated to the scientific and medical communities via publications, presentations, and attendance at major pharmacoepidemiology and pharmacovigilance conferences.
Examples of published Methodology Research from the DSRU
- The Role of the Contextual Cohort to Resolve Some Challenges and Limitations of Comparisons in Pharmacoepidemiology In this paper, we describe the use of the contextual cohort methodology, analyses and interpretation, and its limitations, drawing on experience of this methodology from one of our SCEM studies.
- An analysis of the exclusion criteria used in observational pharmacoepidemiological studies This paper assesses the exclusion criteria used in pharmacoepidemiological research, concluding that there are important differences between investigators in the application of exclusion criteria in pharmacoepidemiological studies.
- How do patients contribute to signal detection? : A retrospective analysis of spontaneous reporting of adverse drug reactions in the UK’s Yellow Card Scheme In this study, the impact that patient-reporting has on signal detection was assessed. We found that patient reporting provides a positive complementary contribution to that of healthcare professionals.