Introduction

Adverse Drug Reactions (ADRs) are a major clinical problem. An understanding of the clinical aspects of ADRs is a fundamental requirement for any professional in the field of pharmacovigilance. This course covers recognition and interpretation of ADRs and their underlying toxopathology and pharmacology. A panel of outstanding multi-disciplinary tutors will provide a comprehensive and up-to-date understanding of all aspects of ADRs through this interactive lecture-based course.

Aims

• To provide delegates with a grounding in and analysis of, the core principles of medical diagnosis including pattern recognition, and therapeutics
• To analyse some of the core concepts of clinical pharmacology relevant to the conduct and interpretation of pharmacoepidemiological research
• To review the mechanisms of drug action, the concept of drug potency, the role of pharmacodynamics and pharmacokinetics (including genetic and immunological factors) in determining variability in drug response and drug interactions
• To review the classification of ADRs and pathophysiology according to body system and associated public health burden

• Principles of medical diagnosis
• Comprehensive and up-to-date understanding of medical and scientific aspects of ADRs
• ADR examples
• Overview of ADRs and interactions
• Genetic and metabolic basis of ADRs
• Immunological aspects of ADRs
• ADRs by system organ class
• Regulatory aspects including guidelines and causality assessment

On completion of this course delegates should be able to:

• Analyse the complexity of undertaking medical diagnoses and the influence of human behaviour (prescriber and patient) and drug factors important in therapeutic decision making
• Critically examine the important features associated with Type A and Type B reactions and identify factors associated with individual susceptibility
• Appraise the rationale for performing clinical investigations and the importance of correct interpretation of results