Past studies

The following is a list of medicines we have studied at the DSRU using various methodologies including Prescription Event Monitoring (PEM), Modified Prescription Event Monitoring (M-PEM) and Specialist Cohort Event Monitoring (SCEM). Some studies were for regulatory and internal purposes only and therefore have not been published. They will not be found when searching for DSRU publications.

PEM studies (in primary care)

Generic drug name Brand Name Group Cohort
Cisapride PREPULSID Antispasmodic 13234
Famotidine PEPCID H2-antagonist 9500
Nizatidine AXID H2-antagonist 7782
Misoprostol CYTOTEC Prostaglandin analogue 13775
Lansoprazole ZOTON Proton pump inhibitor 17329
Omeprazole LOSEC Proton pump inhibitor 16204
Pantoprazole PROTIUM Proton pump inhibitor 11541
Esomeprazole NEXIUM Proton pump inhibitor 11595
Betaxolol KERLONE Beta-blocker 1531
Doxazosin CARDURA Alpha-blocker 8482
Enalapril INNOVACE ACE-inhibitor 15361
Lisinopril ZESTRIL+CARACE ACE-inhibitor 12438
Perindopril COVERSYL ACE-inhibitor 9089
Ramipril TRITACE ACE-inhibitor 1371
Irbesartan APROVEL Antihypertensive 14398
Losartan COZAAR Antihypertensive 14522
Valsartan DIOVAN Antihypertensive 12881
Amlodipine ISTIN Ca-antagonist 12969
Diltiazem TILDIEM Ca-antagonist 10112
Isradipine PRESCAL Ca-antagonist 3679
Mibefradil POSICOR Ca-antagonist 3085
Nicardipine CARDENE Ca-antagonist 10910
Nicorandil IKOREL K-channel activator 13620
Xamoterol CORWIN Inotropic 5373
Fluvastatin LESCOL Lipid-lowering 7542
Bambuterol BAMBEC Beta2 agonist 8098
Eformoterol FORADIL Beta2 agonist 5777
Salmeterol SEREVENT Beta2 agonist 15407
Nedocromil TILADE Asthma 12294
Montelukast SINGULAIR Leukotriene 15612
Zafirlukast ACCOLATE Leukotriene 7976
Acrivastine SEMPREX Antihistamine 7863
Cetirizine ZIRTEK Antihistamine 9554
Fexofenadine TELFAST Antihistamine 16638
Loratadine CLARITYN Antihistamine 9308
Zolpidem STILNOCT Hypnotic 13460
Zopiclone ZIMOVANE Hypnotic 11543
Buspirone BUSPAR Anxiolytic 11113
Olanzapine ZYPREXA Antipsychotic 8858
Risperidone RISPERDAL Antipsychotic 7684
Sertindole SERDOLECT Antipsychotic 436
Moclobemide MANERIX MAOI 10835
Fluoxetine PROZAC SSRI 12692
Fluvoxamine FAVERIN SSRI 10983
Paroxetine SEROXAT SSRI 13741
Sertraline LUSTRAL SSRI 12734
Mirtazapine ZISPIN Antidepressant 13554
Nefazodone DUTONIN Antidepressant 11834
Venlafaxine EFEXOR Antidepressant 12642
Orlistat XENICAL Anti-obesity 16022
Tramadol ZYDOL Analgesic 10532
Sumatriptan IMIGRAN Antimigraine 14928
Lamotrigine LAMICTAL Anti-epileptic 11316
Vigabatrin SABRIL Anti-epileptic 10178
Gabapentin NEURONTIN Anti-epileptic 3100
Donepezil ARICEPT Alzheimer’s treatment 1762
Cefixime SUPRAX Cephalosporin 11250
Azithromycin ZITHROMAX Macrolide 11275
Ciprofloxacin CIPROXIN Quinolone 11477
Enoxacin COMPRECIN Quinolone 2790
Norfloxacin UTINOR Quinolone 11110
Ofloxacin TARIVID Quinolone 11033
Fosfomycin MONURIL Antibacterial 3363
Fluconazole DIFLUCAN Antifungal 15015
Itraconazole SPORANOX Antifungal 13645
Aciclovir ZOVIRAX Antiviral 11051
Famciclovir FAMVIR Antiviral 14169
Valaciclovir VALTREX Antiviral 12804
Acarbose GLUCOBAY Antidiabetic 13655
Repaglinide NOVONORM Antidiabetic 5729
Troglitazone ROMOZIN Antidiabetic 1344
Rosiglitazone AVANDIA Antidiabetic 14418
Pioglitazone ACTOS Antidiabetic 12772
Nateglinide STARLIX Oral antidiabetic 4557
Raloxifene EVISTA Osteoporosis 13987
Risedronate ACTONEL PM Osteoporosis 13643
Finasteride PROSCAR Prostate treatment 14772
Alendronate FOSAMAX Biphosphonate 11916
Tamsulosin FLOMAX MR Alpha-blocker 12484
Terodiline TEROLIN Anticholinergic 12444
Tolterodine DETRUSITOL Anticholinergic 14526
Sildenafil VIAGRA Anti-impotence 22473
Apomorphine UPRIMA Anti-impotence 11185
Bupropion ZYBAN Anti smoking aid 11735
Celecoxib CELEBREX NSAID 17458
Etodolac LODINE NSAID 9091
Meloxicam MOBIC NSAID 19087
Nabumetone RELIFEX NSAID 10444
Rofecoxib VIOXX NSAID 15268
Tenoxicam MOBIFLEX NSAID 10882
Tiotropium SPIRIVA Antimuscarinic Bronchodilator 13892
Rosuvastatin CRESTOR Lipid lowering 11680
Oxcarbazepine TRILEPTAL Anti-epileptic 2243
Desloratadine NEOCLARITYN Antihistamine 11828
Nateglinide STARLIX Anti diabetic 4557
Sibutramine REDUCTIL Anti-obesity 12336
Tadalafil CIALIS Anti-impotence   6266 (cohort 1)
16129 (cohort 2)
Quetiapine SEROQUEL Anti-psychotic 1728
Levocetirizine XYZAL Anti histamine 12876
Tacrolimus PROTOPIC Topical immunomodulator 12895
Vardenafil LEVITRA Anti-impotence 15656
Aripiprazole ABILIFY Anti-psychotic 4955
Testosterone patch INSTRINSA Hormone 3073
Aliskiren RASILEZ Renin inhibitor 6385
Strontium ranelate PROTELOS Bone disease 10865
Etoricoxib ARCOXIA NSAID 12665
Ibandronic acid BONVIVA Osteoporosis 11034
Solifenacin VESICARE Urinary incontinence 11341
Deferasirox EXJADE Iron chelation 122
Duloxetine CYMBALTA/ YENTREVE Antidepressant/ Urinary incontinence 19485

M-PEM Studies (in primary care)

Generic drug name Brand Name Group Cohort
Atomoxetine STRATTERA ADHD treatment 5079
Budesonide PULMICORT Corticosteroid 10408
Carvedilol EUCARDIC Beta blocker 1666
Fentanyl EFFENTORA Opioid analgesic 556
Fentanyl PECFENT Opioid analgesic 63
Fluticasone FLIXOTIDE EVOHALER Corticosteroid 13413
Fluticasone SERETIDE EVOHALER Corticosteroid 13464
Ipratopium bromide ATROVENT Antimuscarinic Bronchodilator 13211
Lumiracoxib PREXIGE NSAID 285
Modafanil PROVIGIL ADHD treatment 2092
Travoprost TRAVATAN Prostaglandin analogue 3528
Varenicline CHAMPIX Nicotinic receptor partial agonist 12135
Ivabridine PROCORALAN Antianginal 4624

SCEM Studies (in secondary care)

Generic drug name Brand Name
Quetiapine XL Seroquel XL (OASIS Study)

Vaccine Studies

Generic drug name Brand Name
Seasonal influenza vaccine Fluenz Tetra Flu Vaccine Feedback Study